![]() Toxoplasma gondii nuclear localisation epigenetics The pipeline is freely available online, uses open access tools and software with user-friendly Perl scripts to automate and manage the results, and is readily adaptable to undertake any such in silico search for genes contributing to particular functions. This identified 57 of the 611 putative epigenetic proteins as likely to be secreted. Step 3 filtered for secretory proteins using SignalP, SecretomeP, and experimental data. This resulted in 611 putative nuclear localised proteins with predicted epigenetic functions. Step 2 uses GOLink to identify proteins of epigenetic function based on Gene Ontology terms. ![]() Step 1 employs PredictNLS and NucPred to identify genes predicted to target eukaryotic nuclei. To identify genes with putative epigenetic functions, we developed an in silico pipeline to interrogate the T. ![]() ![]() Toxoplasma gondii uses epigenetic mechanisms to regulate both endogenous and host cell gene expression. ![]()
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